[HTML][HTML] SARS-CoV-2 vaccines: the advantage of mucosal vaccine delivery and local immunity

J Tobias, P Steinberger, J Wilkinson, G Klais, M Kundi… - Vaccines, 2024 - mdpi.com
Immunity against respiratory pathogens is often short-term, and, consequently, there is an
unmet need for the effective prevention of such infections. One such infectious disease is …

Unraveling the structural and functional dimensions of SARS-CoV2 proteins in the context of COVID-19 pathogenesis and therapeutics

A Jhanwar, D Sharma, U Das - International Journal of Biological …, 2024 - Elsevier
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) has emerged as
the causative agent behind the global pandemic of Coronavirus Disease 2019 (COVID-19) …

Prone-to-Infectivity of Omicron BA. 2 Subvariant from Indonesia on ACE-2 Expressing Cell Lines

W Hidayati, D Hidayati, FL Khairindra… - Journal of Advanced …, 2024 - akademiabaru.com
SARS-CoV-2 virus undergoes mutation, leading to the virus's evolution and modifications in
the characteristics of the virus. Omicron, including BA. 2 subvariant, is currently the …

Profiling of linear B-cell epitopes against human coronaviruses in pooled sera sampled early in the COVID-19 pandemic

E Bach, M Ghanizada, N Kirkby, S Buus, T Osterbye - bioRxiv, 2024 - biorxiv.org
Background: Antibodies play a key role in the immune defence against infectious
pathogens. Understanding the underlying process of B cell recognition is not only of …

Why Should Vaccines against Respiratory Diseases Go Mucosal? B Cell Epitope-Based Vaccines against SARS-CoV-2

J Tobias, P Steinberger, J Wilkinson, G Klais, M Kundi… - 2024 - preprints.org
Immunity against respiratory pathogens is often short-term, and consequently there is an
unmet need for effective prevention of such infections. One such infectious disease is COVID …

Development of an Aptamer-functionalized Magnetic Particle Sample Purification Protocol for the Plasmonic Polymerase Chain Reaction Diagnosis of Severe Acute …

A Resendes - 2024 - escholarship.mcgill.ca
Background Despite having endured numerous pandemics throughout history and working
with 21st century technology, the world was still unprepared to deal with the emergence of …

SARS-CoV-2 exposed: cell cycle disruption and CRISPR-Cas knockdown

K Andersson - 2024 - openarchive.ki.se
Coronaviruses showed their capacity to spread to pandemic levels during the COVID-19
pandemic. Their ability to rapidly spread and to cause severe disease has made them a …

Repurposing Kinase Inhibitors for COVID-19 A Comprehensive Review of Antiviral and Immunomodulatory Effects

R Bhat, G Palakki, M Uday, V Karicheri… - International Journal of …, 2024 - ijphi.com
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has posed significant global
challenges, impacting millions and straining healthcare systems. With over 600 million …

Structural and functional characterization of a humanized neutralizing antibody targeting the SARS-CoV-2 Receptor Binding Domain (RBD)

A Costanzo - 2024 - tesidottorato.depositolegale.it
Abstract SARS-CoV-2, responsible for the ongoing global pandemic, utilizes its spike protein
(S protein) to mediate viral entry by interacting with host cell receptors. Since 2020, several …

Entry of Enveloped Viruses into Host Cells: Membrane Fusion

V Mas, JA Melero - Structure and Physics of Viruses: An Integrated Guide, 2024 - Springer
Viruses are intracellular parasites that hijack the cellular machinery for their own replication.
Therefore, an obligatory step in the virus life cycle is the delivery of the viral genome inside …