The balance between immune effector cells and immunosuppressive cells and how this
regulates the tumor microenvironment has been well described. A significant contribution of …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

To assess the importance of B cell control of T cell differentiation, we analyzed the course of
the T helper type 1 (TH1)-driven disease experimental autoimmune encephalomyelitis in …

B cells possess a variety of immune functions that are involved in normal and abnormal
immune responses, including autoimmune disorders. Through murine models of intestinal …

The immune system plays a crucial role in cancer development either by fostering tumor
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …

Although recent animal studies have fuelled growing interest in Ab-independent functions of
B cells, relatively little is known about how human B cells and their subsets may contribute to …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

B cell abnormalities contribute to the development and progress of autoimmune disease.
Traditionally, the role of B cells in autoimmune disease was thought to be predominantly …

The release of extracellular vesicles (EV) by the syncytiotrophoblast (STB) may be an
important mechanism by which the placenta signals to the mother. STB derived EV (STBEV) …

B cell depletion significantly reduces the burden of several immune-mediated diseases.
However, B cell activation has been until now associated with a protection against …