Skeletal muscle fibers are large syncytia but it is currently unknown whether gene
expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq …

Mammalian skeletal muscles are composed of two major fibre types (I and II) that differ in
terms of size, metabolism and contractile properties. In general, slow‐twitch type I fibres are …

SIX homeoproteins were first described in Drosophila, where they participate in the Pax-Six-
Eya-Dach (PSED) network with eyeless, eyes absent and dachsund to drive synergistically …

The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform
content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping …

Emerging studies indicate important roles for non-coding RNAs (ncRNAs) as essential
regulators in myogenesis, but relatively less is known about their function. In our previous …

Muscle cells have different phenotypes adapted to different usage, and can be grossly
divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of …

Mechanosensing and subsequent mechanotransduction are indispensable for muscle
plasticity. Nevertheless, a scarcity of literature exists regarding an all-encompassing …

The widespread presence of slow-red and fast-white muscles in all vertebrates supports the
evolutionary advantage of having two types of motors available for animal movement—a …

Four SIX homeoproteins display a combinatorial expression throughout embryonic
developmental myogenesis and they modulate the expression of the myogenic regulatory …

The kinetics of myosin controls the speed and power of muscle contraction. Mammalian
skeletal muscles express twelve kinetically different myosin heavy chain (MyHC) genes …