Current trends in toxicity assessment of herbal medicines: A narrative review
Even in modern times, the popularity level of medicinal plants and herbal medicines in
therapy is still high. The World Health Organization estimates that 80% of the population in …
therapy is still high. The World Health Organization estimates that 80% of the population in …
Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids
Pyrrolizidine alkaloids (PAs) and PA N-oxides are common phytotoxins produced by over
6000 plant species. Humans are frequently exposed to PAs via ingestion of PA-containing …
6000 plant species. Humans are frequently exposed to PAs via ingestion of PA-containing …
Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites
Y He, W Lian, L Ding, X Fan, J Ma, QY Zhang… - Archives of …, 2021 - Springer
Pyrrolizidine alkaloids (PAs) are common phytotoxins with both hepatotoxicity and
pneumotoxicity. Hepatic cytochrome P450 enzymes are known to bioactivate PAs into …
pneumotoxicity. Hepatic cytochrome P450 enzymes are known to bioactivate PAs into …
Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery
M Haas, K Wirachowski, L Thibol, JH Küpper… - Archives of …, 2023 - Springer
Pyrrolizidine alkaloids (PAs) occur as contaminants in plant-based foods and herbal
medicines. Following metabolic activation by cytochrome P450 (CYP) enzymes, PAs induce …
medicines. Following metabolic activation by cytochrome P450 (CYP) enzymes, PAs induce …
Mass spectrometric analysis strategies for pyrrolizidine alkaloids
Y Chen, L Li, J Xu, Y Liu, Y Xie, A Xiong, Z Wang… - Food Chemistry, 2024 - Elsevier
Pyrrolizidine alkaloids (PAs) in food and natural preparations have received widespread
attention due to their hepatotoxicity, genotoxicity, and embryotoxicity. Mass spectrometry …
attention due to their hepatotoxicity, genotoxicity, and embryotoxicity. Mass spectrometry …
Chromatographic methods for detection and quantification of pyrrolizidine alkaloids in flora, herbal medicines, and food: an overview
AC Sousa, C Ribeiro, VMF Gonçalves… - Critical Reviews in …, 2024 - Taylor & Francis
Pyrrolizidine alkaloids (PAs) are natural toxins produced by some plants that gained special
interest due to their potential hazardous effects in humans and animals. These substances …
interest due to their potential hazardous effects in humans and animals. These substances …
Hepatic phytotoxins in herbal medicines: a review of Africa's pyrrolizidine alkaloid-containing plants, their traditional uses, contamination pathways and associated …
Incidences of human exposure to pyrrolizidine alkaloids (PAs) and their adverse effects
have previously been reported in three African countries. In view of the increasing intake of …
have previously been reported in three African countries. In view of the increasing intake of …
OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects
M Haas, G Ackermann, JH Küpper, H Glatt… - Archives of …, 2023 - Springer
Pyrrolizidine alkaloids (PAs) are important plant hepatotoxins, which occur as contaminants
in plant-based foods, feeds and phytomedicines. Numerous studies demonstrated that the …
in plant-based foods, feeds and phytomedicines. Numerous studies demonstrated that the …
[HTML][HTML] The chemical structure impairs the intensity of genotoxic effects promoted by 1, 2-unsaturated pyrrolizidine alkaloids in vitro
J Buchmueller, AM Enge, A Peters, J Ebmeyer… - Food and Chemical …, 2022 - Elsevier
unsaturated pyrrolizidine alkaloids (PAs) represent a large group of secondary plant
metabolites exhibiting hepatotoxic, genotoxic, and carcinogenic properties upon …
metabolites exhibiting hepatotoxic, genotoxic, and carcinogenic properties upon …
Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels
F Widjaja, Y Alhejji, J Yangchen… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope This study aims to determine if previously developed physiologically‐based kinetic
(PBK) model in rat can be modified for senecionine (SEN) and its N‐oxide (SENO), and be …
(PBK) model in rat can be modified for senecionine (SEN) and its N‐oxide (SENO), and be …