Atrial fibrillation: pathogenesis, predisposing factors, and genetics

M Sagris, EP Vardas, P Theofilis… - International journal of …, 2021 - mdpi.com
Atrial fibrillation (AF) is the most frequent arrhythmia managed in clinical practice, and it is
linked to an increased risk of death, stroke, and peripheral embolism. The Global Burden of …

Molecular and cellular mechanisms of atrial fibrosis in atrial fibrillation

S Nattel - JACC: Clinical Electrophysiology, 2017 - jacc.org
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Atrial fibrosis has
emerged as an important pathophysiological contributor and has been linked to AF …

Left atrial fibrosis in atrial fibrillation: Mechanisms, clinical evaluation and management

J Ma, Q Chen, S Ma - Journal of cellular and molecular …, 2021 - Wiley Online Library
Atrial fibrillation (AF), the commonest arrhythmia, shows associations with various disease
conditions. Mounting evidence indicates that atrial fibrosis is an important part of the …

Electrophysiological consequences of cardiac fibrosis

S Verheule, U Schotten - Cells, 2021 - mdpi.com
For both the atria and ventricles, fibrosis is generally recognized as one of the key
determinants of conduction disturbances. By definition, fibrosis refers to an increased …

Atrial fibrosis underlying atrial fibrillation

CY Li, JR Zhang, WN Hu, SN Li - … journal of molecular …, 2021 - spandidos-publications.com
Atrial fibrillation (AF) is one of the most common tachyarrhythmias observed in the clinic and
is characterized by structural and electrical remodelling. Atrial fibrosis, an emblem of atrial …

Sulfide regulation of cardiovascular function in health and disease

GK Kolluru, RE Shackelford, X Shen… - Nature Reviews …, 2023 - nature.com
Hydrogen sulfide (H2S) has emerged as a gaseous signalling molecule with crucial
implications for cardiovascular health. H2S is involved in many biological functions …

Remodeling of cardiac gap junctional cell–cell coupling

S Dhein, A Salameh - Cells, 2021 - mdpi.com
The heart works as a functional syncytium, which is realized via cell-cell coupling
maintained by gap junction channels. These channels connect two adjacent cells, so that …

Constructing a human atrial fibre atlas

CH Roney, R Bendikas, F Pashakhanloo… - Annals of biomedical …, 2021 - Springer
Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant
drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy …

Prevalence and predictors of low voltage zones in the left atrium in patients with atrial fibrillation

Y Huo, T Gaspar, M Pohl, J Sitzy, U Richter… - EP …, 2018 - academic.oup.com
Aims To describe the extent and distribution of low voltage zones (LVZ) in a large cohort of
patients undergoing ablation for paroxysmal and persistent atrial fibrillation (AF), and to …

MicroRNAs in atrial fibrillation: from expression signatures to functional implications

NWE van den Berg, M Kawasaki, WR Berger… - … Drugs and Therapy, 2017 - Springer
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with
pronounced morbidity and mortality. Its prevalence, expected to further increase for the …