Compared with rapid accumulation of protein sequences from high-throughput DNA
sequencing, obtaining experimental 3D structures of proteins is still much more difficult …

The ever increasing computer power, together with the improved accuracy of atomistic force
fields, enables researchers to investigate biological systems at the molecular level with …

A predictive coarse-grained protein force field [associative memory, water-mediated,
structure, and energy model for molecular dynamics (AWSEM)-MD] is used to study the …

The associative memory, water-mediated, structure and energy model (AWSEM) has been
successfully used to study protein folding, binding, and aggregation problems. In this work …

Huntington's disease (HD) is a neurodegenerative disease caused by an abnormal
expansion in the polyglutamine (polyQ) track of the Huntingtin (HTT) protein. The severity of …

The biological activity of proteins depends on their three-dimensional structure, known as
the native state. The main force driving the correct folding mechanism is the hydrophobic …

Intrinsically disordered proteins (IDPs) lack a rigid three-dimensional structure and populate
a polymorphic ensemble of conformations. Because of the lack of a reference conformation …

With the completion of the human genome project at the beginning of the 21st century, the
biological sciences entered an unprecedented age of data generation, and made its first …

Intense study of intrinsically disordered proteins (IDPs) did not begin in earnest until the late
1990s when a few groups, working independently, convinced the community that these …

Abstract Prostate-associated gene 4 (PAGE4) is an intrinsically disordered protein
implicated in prostate cancer. Thestress-response kinase homeodomain-interacting protein …