Engineered biomaterials for in situ tissue regeneration

AK Gaharwar, I Singh, A Khademhosseini - Nature Reviews Materials, 2020 - nature.com
In situ tissue regeneration harnesses the body's regenerative potential to control cell
functions for tissue repair. The design of biomaterials for in situ tissue engineering requires …

Protective functions of reactive astrocytes following central nervous system insult

M Linnerbauer, V Rothhammer - Frontiers in immunology, 2020 - frontiersin.org
Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

C Sousa, A Golebiewska, SK Poovathingal… - EMBO …, 2018 - embopress.org
Microglia are specialized parenchymal‐resident phagocytes of the central nervous system
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …

Effects of neurotrophic factors in glial cells in the central nervous system: expression and properties in neurodegeneration and injury

S Pöyhönen, S Er, A Domanskyi… - Frontiers in physiology, 2019 - frontiersin.org
Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

A single-cell survey of Drosophila blood

SG Tattikota, B Cho, Y Liu, Y Hu, V Barrera… - Elife, 2020 - elifesciences.org
Drosophila blood cells, called hemocytes, are classified into plasmatocytes, crystal cells,
and lamellocytes based on the expression of a few marker genes and cell morphologies …

Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors

A Gonzalez-Cordero, K Kruczek, A Naeem… - Stem cell reports, 2017 - cell.com
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …

N2‐Polarized Neutrophils Guide Bone Mesenchymal Stem Cell Recruitment and Initiate Bone Regeneration: A Missing Piece of the Bone Regeneration Puzzle

B Cai, D Lin, Y Li, L Wang, J Xie, T Dai, F Liu… - Advanced …, 2021 - Wiley Online Library
The role of neutrophils in bone regeneration remains elusive. In this study, it is shown that
intramuscular implantation of interleukin‐8 (IL‐8)(commonly recognized as a chemotactic …

[HTML][HTML] Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives

SJ Gasparini, S Llonch, O Borsch, M Ader - Progress in retinal and eye …, 2019 - Elsevier
The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

Rational design of hydrogels for immunomodulation

W Bu, Y Wu, AM Ghaemmaghami… - Regenerative …, 2022 - academic.oup.com
The immune system protects organisms against endogenous and exogenous harm and
plays a key role in tissue development, repair and regeneration. Traditional …

Rejuvenating strategies for stem cell-based therapies in aging

J Neves, P Sousa-Victor, H Jasper - Cell stem cell, 2017 - cell.com
Recent advances in our understanding of tissue regeneration and the development of
efficient approaches to induce and differentiate pluripotent stem cells for cell replacement …