Non-canonical hedgehog signaling pathway in cancer: activation of GLI transcription factors beyond smoothened
S Pietrobono, S Gagliardi, B Stecca - Frontiers in genetics, 2019 - frontiersin.org
The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …
role in controlling cell specification, cell–cell interaction and tissue patterning during …
[HTML][HTML] Basal cell carcinoma: pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management.
AG Marzuka, SE Book - The Yale journal of biology and medicine, 2015 - europepmc.org
Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the
most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog …
most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog …
High burden and pervasive positive selection of somatic mutations in normal human skin
How somatic mutations accumulate in normal cells is central to understanding cancer
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …
Basal cell carcinoma: from pathophysiology to novel therapeutic approaches
Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype
of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an …
of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an …
In situ identification of bipotent stem cells in the mammary gland
The mammary epithelium undergoes profound morphogenetic changes during
development. Architecturally, it comprises two primary lineages, the inner luminal and outer …
development. Architecturally, it comprises two primary lineages, the inner luminal and outer …
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most
commonly KRASG12D, that result in a dominant-active form of the KRAS GTPase. However …
commonly KRASG12D, that result in a dominant-active form of the KRAS GTPase. However …
[HTML][HTML] Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches
SC Peterson, M Eberl, AN Vagnozzi, A Belkadi… - Cell stem cell, 2015 - cell.com
Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to
constitutive activation of the Hedgehog pathway. Although the requirement for Hedgehog in …
constitutive activation of the Hedgehog pathway. Although the requirement for Hedgehog in …
Obesity accelerates hair thinning by stem cell-centric converging mechanisms
H Morinaga, Y Mohri, M Grachtchouk, K Asakawa… - Nature, 2021 - nature.com
Obesity is a worldwide epidemic that predisposes individuals to many age-associated
diseases, but its exact effects on organ dysfunction are largely unknown. Hair follicles—mini …
diseases, but its exact effects on organ dysfunction are largely unknown. Hair follicles—mini …
Epithelial stem cells, wound healing and cancer
EN Arwert, E Hoste, FM Watt - Nature Reviews Cancer, 2012 - nature.com
It is well established that tissue repair depends on stem cells and that chronic wounds
predispose to tumour formation. However, the association between stem cells, wound …
predispose to tumour formation. However, the association between stem cells, wound …
The Hedgehog's tale: developing strategies for targeting cancer
JMY Ng, T Curran - Nature Reviews Cancer, 2011 - nature.com
Research into basic developmental biology has frequently yielded insights into cancer
biology. This is particularly true for the Hedgehog (HH) pathway. Activating mutations in the …
biology. This is particularly true for the Hedgehog (HH) pathway. Activating mutations in the …