Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …

The incidence of many types of cancer arising in organs with non-reproductive functions is
significantly higher in male populations than in female populations, with associated …

Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by glycogen-laden,
unexplained male predominance, and frequent mutations in the Von Hippel-Lindau (VHL) …

DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …

The genetic abnormalities that drive tumorigenesis are usually coupled with epigenetic
alterations, such as DNA methylation and aberrant histone modifications, which may help …

During development, chromatin-modifying enzymes regulate both the timely establishment
of cell-type-specific gene programs and the coordinated repression of alternative cell fates …