The progression of cancer involves not only the gradual evolution of cells by mutations in
DNA but also alterations in the gene expression induced by those mutations and input from …

The homeobox (HOX) genes encoding an evolutionarily highly conserved family of
homeodomain-containing transcriptional factors are essential for embryogenesis and …

Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear
whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic …

Background: Accumulating studies manifest that BTB and CNC homology 1 (BACH1)
facilitates multiple malignancies progression and metastasis, and targeting the BACH1 …

Transcriptional deregulation, a cancer cell hallmark, is driven by epigenetic abnormalities in
the majority of brain tumors, including adult glioblastoma and pediatric brain tumors …

The HOX genes are a highly conserved group of transcription factors that have key roles in
early development, but which are also highly expressed in most cancers. Many studies have …

Oncogenic KRAS mutations develop unique metabolic dependencies on nutrients to support
tumor metabolism and cell proliferation. In particular, KRAS mutant cancer cells exploit …

Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a
crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the …

Transcription factors, cofactors, chromatin regulators, and transcription apparatuses interact
with transcriptional regulatory elements, including promoters, enhancers, and super …

Colorectal cancer (CRC) is a malignant tumor initiating from the mucosa of the colorectum.
According to the 2020 statistics from the World Health Organization, there are 10.0% CRC …