Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allelic
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …

To capture the full spectrum of genetic risk for autism, we performed a two-stage analysis of
rare de novo and inherited coding variants in 42,607 autism cases, including 35,130 new …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

With few exceptions, the marked advances in knowledge about the genetic basis of
schizophrenia have not converged on findings that can be confidently used for precise …

By analyzing the exomes of 12,332 unrelated Swedish individuals, including 4,877
individuals affected with schizophrenia, in ways informed by exome sequences from 45,376 …

RNA-binding proteins (RBPs) are key players in the post-transcriptional regulation of gene
expression. Precise knowledge about their binding sites is therefore critical to unravel their …

Neuroticism is a personality trait of fundamental importance for psychological well-being and
public health. It is strongly associated with major depressive disorder (MDD) and several …

Human-specific genomic changes contribute to the unique functionalities of the human
brain,,,–. The cellular heterogeneity of the human brain, and the complex regulation of gene …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …