Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Covering: up to July 2015 Nonribosomal peptides are amongst the most widespread and
structurally diverse secondary metabolites in nature with many possessing bioactivity that …

Covering: 2003 to 2009 The quest for new antibiotics, especially those with activity against
Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in …

The discovery of nonproteinogenic amino acids among natural products, either in native
state or as fragments of complex molecules, has increased the level of interest in this family …

Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant
microorganisms. Numerous natural nucleosides and their synthetically modified analogues …

The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply
of new antibiotics. It is therefore of great importance to find and create new antibiotics …

Introduction of prnA, the halogenase gene from pyrrolnitrin biosynthesis, into Streptomyces
coeruleorubidus resulted in efficient in situ chlorination of the uridyl peptide antibotic …

Covering: up to the end of 2013 Cu-mediated C (sp2)–N bond formation has received
intense interest recently, and has been applied to the total synthesis of a wide variety of …

Because of extraordinary structural diversity and broad biological activities, natural products
have played a significant role in drug discovery. These therapeutically important secondary …