Tau-targeting therapies for Alzheimer disease: current status and future directions
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
Tau-targeting therapies for Alzheimer disease
EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ …
In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …
SARS‐CoV‐2 targets neurons of 3D human brain organoids
A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency.
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …
[HTML][HTML] Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common
type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD …
type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD …
Invited review: neuropathology of tauopathies: principles and practice
GG Kovacs - Neuropathology and applied neurobiology, 2015 - Wiley Online Library
Tauopathies are clinically, morphologically and biochemically heterogeneous
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …
Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy
A Kondo, K Shahpasand, R Mannix, J Qiu, J Moncaster… - Nature, 2015 - nature.com
Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the
best known environmental risk factors for chronic traumatic encephalopathy and Alzheimer's …
best known environmental risk factors for chronic traumatic encephalopathy and Alzheimer's …
A walk through tau therapeutic strategies
S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …
and related human tauopathies. There is a growing body of evidence indicating that …
GSK-3β, a pivotal kinase in Alzheimer disease
M Llorens-Marítin, J Jurado, F Hernández… - Frontiers in molecular …, 2014 - frontiersin.org
Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …
Tau proteins and tauopathies in Alzheimer's disease
Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
function deficits. There are two major pathological hallmarks that contribute to the …
function deficits. There are two major pathological hallmarks that contribute to the …