Lamotrigine is a new antiepileptic agent chemically unrelated to any established drugs in
use. The drug can be estimated in biological fluids by high performance liquid …

Synopsis Lamotrigine is an antiepileptic drug which is believed to suppress seizures by
inhibiting the release of excitatory neurotransmitters. Efficacy has been demonstrated for …

Purpose: To assess the comparative therapeutic value of valproate (VPA), lamotrigine (LTG),
and their combination in patients with complex partial seizures resistant to other established …

The mean steady-state plasma concentration of lamotrigine (LTG) was 13 μmol/L in 22
women taking LTG in combination oral contraceptives (OC) compared with 28 μmol/L …

Although it is known that the use of oral contraceptives (OC's) can induce glucuronide
conjugating enzymes, currently no data exists as to the potential that the elimination of the …

Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed.
A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was …

This prospective study was designed to ascertain whether measurement of lamotrigine
(LTG) concentrations in the epilepsy clinic could be used to predict the onset of complete …

The method involves precipitation of plasma proteins with acetonitrile and analysis of the
supernatant by high-performance liquid chromatography using a 5 μm Zorbax C8 column …

A rapid, sensitive and simple high-performance liquid chromatographic (HPLC) method for
the determination of lamotrigine in plasma is described. The drug was extracted from 100 μl …

A reversed-phase high-performance liquid chromatography assay was developed and
validated to determine plasma and brain lamotrigine concentrations allowing …