Acute kidney injury is an increasingly common complication of hospital admission and is
associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult …

The Wnt/β-catenin signaling pathway plays important roles in embryonic development and
tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the …

Organogenesis generates higher-order structures containing functional subunits, connective
components, and progenitor niches. Despite recent advances in organoid-based modeling …

The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of
acid-base homeostasis. However, in recent years the understanding of the function of the …

Congenital abnormalities of the kidney and urinary tract (CAKUT) occur in 1 out of 500
newborns, and constitute approximately 20–30% of all anomalies identified in the prenatal …

There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed
commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin …

Bardet-Biedl syndrome (BBS) is a multisystemic disorder typified by developmental and
progressive degenerative defects. A combination of genetic, in vitro, and in vivo studies have …

Mammalian nephrons form as a result of a complex morphogenesis and patterning of a
simple epithelial precursor, the renal vesicle. Renal vesicles are established from a …