Pharmacology and toxicology are part of a much broader effort to understand the
relationship between chemistry and biology. While biomedicine has necessarily focused on …

The correct maintenance and differentiation of hematopoietic stem cells (HSC) in bone
marrow is vital for the maintenance and operation of the human blood system. GATA2 plays …

The zebrafish has proven to be a valuable model organism for studying hematopoiesis, but
relatively little is known about zebrafish immune cell development and functional diversity …

Despite recent advances in single-cell genomics, the lack of maps for single-cell candidate
cis-regulatory elements (cCREs) in non-mammal species has limited our exploration of …

The importance of predisposition to leukaemia in clinical practice is being increasingly
recognized. This is emphasized by the establishment of a novel WHO disease category in …

Abstract Isocitrate dehydrogenase 2 (IDH2) mutations occur in more than 15% of
cytogenetically normal acute myeloid leukemia (CN-AML) but comparative studies of their …

In fishes and salamanders, but not mammals, neural stem cells switch back to neurogenesis
after injury. The signalling environment of neural stem cells is strongly altered by the …

Transcription factors (TFs) are crucial epigenetic regulators, which enable cells to
dynamically adjust gene expression in response to environmental signals. Computational …

Congenital neutropenia: disease models guiding new treatment... : Current Opinion in
Hematology Congenital neutropenia: disease models guiding new treatment strategies : Current …

Evidence exists suggesting the anti‐depressive activities of geniposide (GP), a major
compound in Gardenia jasminoides Ellis. Accordingly, the present study attempts to explore …