Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation
and compose the complex nervous system. Wnt signaling is thought to control the balance of …

The majority of animal phyla have species that can regenerate. Comparing regeneration
across animals can reconstruct the molecular and cellular evolutionary history of this …

Hydra's almost unlimited regenerative potential is based on Wnt signaling, but so far it is
unknown how the injury stimulus is transmitted to discrete patterning fates in head and foot …

The Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family.
It appears to be conserved in all animal species where it regulates important physiological …

The interrelationship between endogenous microbiota, the immune system, and tissue
regeneration is an area of intense research due to its potential therapeutic applications. We …

Mechanisms enabling positional identity re-establishment are likely critical for tissue
regeneration. Planarians use Wnt/beta-catenin signaling to polarize the termini of their …

Planaria are complex metazoans that repair damage to their bodies and cease remodeling
when a correct anatomy has been achieved. This model system offers a unique opportunity …

Background Metazoan lineages exhibit a wide range of regenerative capabilities that vary
among developmental stage and tissue type. The most robust regenerative abilities are …

Many animal species are capable of replacing missing tissues that are lost upon injury or
amputation through the process of regeneration. Although the extent of regeneration is …

Understanding how some animals are immortal and avoid the ageing process is important.
We currently know very little about how they achieve this. Research with genetic model …