Polymeric nanoparticle vaccines to combat emerging and pandemic threats

D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …

Materials for immunotherapy

CW Shields IV, LLW Wang, MA Evans… - Advanced …, 2020 - Wiley Online Library
Breakthroughs in materials engineering have accelerated the progress of immunotherapy in
preclinical studies. The interplay of chemistry and materials has resulted in improved …

Recent advances in polymeric nanoparticle-encapsulated drugs against intracellular infections

A Sánchez, SP Mejía, J Orozco - Molecules, 2020 - mdpi.com
Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat
intracellular infections. They have outstanding performance in delivering antimicrobials …

Pulmonary delivery of rifampicin-loaded soluplus micelles against Mycobacterium tuberculosis

E Grotz, NL Tateosian, J Salgueiro, E Bernabeu… - Journal of Drug Delivery …, 2019 - Elsevier
Tuberculosis (TB) stands as the second “most deadly infectious disease” behind AIDS.
Rifampicin (RIF) represents one of the most effective anti-TB drugs of the “short-term” oral TB …

Expanding the arsenal against pulmonary diseases using surface-functionalized polymeric micelles: Breakthroughs and bottlenecks

R Khursheed, KR Paudel, M Gulati, S Vishwas… - …, 2022 - Taylor & Francis
Pulmonary diseases such as lung cancer, asthma and tuberculosis have remained one of
the common challenges globally. Polymeric micelles (PMs) have emerged as an effective …

[HTML][HTML] Harnessing donor unrestricted T-cells for new vaccines against tuberculosis

SA Joosten, THM Ottenhoff, DM Lewinsohn, DF Hoft… - Vaccine, 2019 - Elsevier
Abstract Mycobacterium bovis bacille Calmette-Guérin (BCG) prevents extrapulmonary
tuberculosis (TB) and death among infants but fails to consistently and sufficiently prevent …

A review on recent advances in nanomedicines for the treatment of pulmonary tuberculosis

KR Chaudhary, V Puri, A Singh, C Singh - Journal of Drug Delivery Science …, 2022 - Elsevier
Tuberculosis (TB) has been the most life-threatening contagious disease caused by
pathogenic mycobacterium tuberculosis. The World Health Organization (WHO) report, 2020 …

The combination of morphology and surface chemistry defines the immunological identity of nanocarriers in human blood

MP Vincent, NB Karabin, SD Allen… - Advanced …, 2021 - Wiley Online Library
Upon exposure to blood, a corona of proteins adsorbs to nanocarrier surfaces to confer a
biological identity that interfaces with the immune system. While the nanocarrier surface …

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

P Ruibal, L Voogd, SA Joosten… - Immunological …, 2021 - Wiley Online Library
Vaccination strategies against mycobacteria, focusing mostly on classical T‐and B‐cells,
have shown limited success, encouraging the addition of alternative targets. Classically …

Quantitative comparison of three widely-used pulmonary administration methods in vivo with radiolabeled inhalable nanoparticles

L Wu, C Rodríguez-Rodríguez, D Cun, M Yang… - European Journal of …, 2020 - Elsevier
Pulmonary formulations have been attracting much attention because of their direct effects
on respiratory diseases, but also their non-invasive administration for the treatment of …