Clinical significance of FBXW7 loss of function in human cancers

J Fan, M Bellon, M Ju, L Zhao, M Wei, L Fu, C Nicot - Molecular cancer, 2022 - Springer
Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7)(also referred to as FBW7 or
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …

Mechanisms of long non-coding RNAs in cancers and their dynamic regulations

XZ Zhang, H Liu, SR Chen - Cancers, 2020 - mdpi.com
Long non-coding RNA (lncRNA), which is a kind of noncoding RNA, is generally
characterized as being more than 200 nucleotide transcripts in length. LncRNAs exhibit …

LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma

Y Liu, M Shi, X He, Y Cao, P Liu, F Li, S Zou… - Journal of hematology & …, 2022 - Springer
Background LncRNA-PACERR plays critical role in the polarization of tissue-associated
macrophages (TAMs). In this study, we found the function and molecular mechanism of …

High-metastatic cancer cells derived exosomal miR92a-3p promotes epithelial-mesenchymal transition and metastasis of low-metastatic cancer cells by regulating …

B Yang, X Feng, H Liu, R Tong, J Wu, C Li, H Yu… - Oncogene, 2020 - nature.com
Exosomes play an important role in intercellular communication and metastatic progression
of hepatocellular carcinoma (HCC). However, cellular communication between …

[HTML][HTML] The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination

G Huang, Z Xiang, H Wu, Q He, R Dou… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Ferroptosis is a novel form of cell death that is closely associated with the formation of many
tumors. Our study focused on the mechanism by which long noncoding RNAs (lncRNAs) …

A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer

H Cui, H Li, H Wu, F Du, X Xie, S Zeng, Z Zhang… - Cell Death & …, 2022 - nature.com
At present, it is commonly believed that tRFs and tiRNAs are formed by the specific and
selective shear of tRNAs under certain pressure stimulation, rather than by random …

Chitosan‐gelatin‐EGCG nanoparticle‐meditated LncRNA TMEM44‐AS1 silencing to activate the P53 signaling pathway for the synergistic reversal of 5‐FU resistance …

M Zhou, J Dong, J Huang, W Ye, Z Zheng… - Advanced …, 2022 - Wiley Online Library
Chemoresistance is one of the leading causes of therapeutic failure in gastric cancer (GC)
treatment. Recent studies have shown lncRNAs play pivotal roles in regulating GC …

lncRNA-Xist/miR-101-3p/KLF6/C/EBPα axis promotes TAM polarization to regulate cancer cell proliferation and migration

Y Zhao, Z Yu, R Ma, Y Zhang, L Zhao, Y Yan… - … Therapy-Nucleic Acids, 2021 - cell.com
The phenotypic switch in tumor-associated macrophages (TAMs) mediates immunity escape
of cancer. However, the underlying mechanisms in the TAM phenotypic switch have not …

A novel cuproptosis-related prognostic lncRNA signature and lncRNA MIR31HG/miR-193a-3p/TNFRSF21 regulatory axis in lung adenocarcinoma

X Mo, D Hu, P Yang, Y Li, S Bashir, A Nai, F Ma… - Frontiers in …, 2022 - frontiersin.org
Lung adenocarcinoma (LUAD) remains the most common subtype of lung malignancy.
Cuproptosis is a newly identified cell death which could regulate tumor cell proliferation and …

Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications

H Ming, B Li, L Zhou, A Goel, C Huang - Biochimica et Biophysica Acta …, 2021 - Elsevier
Cancer metastasis, defined by the epithelial to mesenchymal transition (EMT) of tumor cells,
disseminates from the primary site to progressively colonize in distant tissues, and accounts …