Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation

M Xue, VW Yong - The Lancet Neurology, 2020 - thelancet.com
Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …

Minocycline: far beyond an antibiotic

N Garrido‐Mesa, A Zarzuelo… - British journal of …, 2013 - Wiley Online Library
Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade

J Vandooren, PE Van den Steen… - Critical reviews in …, 2013 - Taylor & Francis
Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Preclinical and clinical research on inflammation after intracerebral hemorrhage

J Wang - Progress in neurobiology, 2010 - Elsevier
Intracerebral hemorrhage (ICH) is one of the most lethal stroke subtypes. Despite the high
morbidity and mortality associated with ICH, its pathophysiology has not been investigated …

Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: an update

H Ren, R Han, X Chen, X Liu, J Wan… - Journal of Cerebral …, 2020 - journals.sagepub.com
Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities

Q Bai, M Xue, VW Yong - Brain, 2020 - academic.oup.com
The prognosis of intracerebral haemorrhage continues to be devastating despite much
research into this condition. A prominent feature of intracerebral haemorrhage is …

[HTML][HTML] Therapeutic strategies for intracerebral hemorrhage

Z Li, S Khan, Y Liu, R Wei, VW Yong, M Xue - Frontiers in Neurology, 2022 - frontiersin.org
Stroke is the second highest cause of death globally, with an increasing incidence in
developing countries. Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes …

[HTML][HTML] Necrosulfonamide Alleviates Acute Brain Injury of Intracerebral Hemorrhage via Inhibiting Inflammation and Necroptosis

X Zhang, Y Zhang, F Wang, Y Liu, VW Yong… - Frontiers in molecular …, 2022 - frontiersin.org
Objective Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, without
effective treatment. Necrosulfonamide (NSA), a specific inhibitor for mixed lineage kinase …

Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury

Z Wang, J Nong, RB Shultz, Z Zhang, T Kim, VJ Tom… - Biomaterials, 2017 - Elsevier
Many mechanisms contribute to the secondary injury cascades following traumatic spinal
cord injury (SCI). However, most current treatment strategies only target one or a few …