Human osteoarthritis is a systemic musculoskeletal disorder involving activation of innate
and adaptive immune systems accompanied by inflammation exemplified by the elevated …

An imbalance in gene expressional events skewing chondrocyte anabolic and catabolic
pathways toward the latter causes an aberrant turnover and loss of extracellular matrix …

Abstract Changes in the composition and viscoelasticity of the extracellular matrix in load-
bearing cartilage influence the proliferation and phenotypes of chondrocytes, and are …

Introduction This study aimed to evaluate whether profiles of several soluble mediators in
synovial fluid and cartilage tissue are pathology-dependent and how their production is …

Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of
cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and …

The spatiotemporal proteome of the intervertebral disc (IVD) underpins its integrity and
function. We present DIPPER, a deep and comprehensive IVD proteomic resource …

In recent years, the mathematical and computational sciences have developed novel
methodologies and insights that can aid in designing advanced bioreactors, microfluidic …

Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in
the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) …

We now want to begin to develop a holistic view of cartilage as a tissue that has an
integrated set of homeostatic processes for maintaining itself. In the context of other tissues …

In osteoarthritis (OA), chondrocyte metabolism dysregulation increases relative catabolic
activity, which leads to cartilage degradation. To enable the semiquantitative interpretation …