The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

Drosophila melanogaster has been a key model in developing our current understanding of
the molecular mechanisms of ageing. Of particular note is its role in establishing the …

Identified as a hallmark of cancer, metabolic reprogramming allows cancer cells to rapidly
proliferate, resist chemotherapies, invade, metastasize, and survive a nutrient-deprived …

A central question in cell and developmental biology is how the information encoded in the
genome is differentially interpreted to generate a diverse array of cell types. A growing body …

In Drosophila, the fat body, functionally equivalent to the mammalian liver and adipocytes,
plays a central role in regulating systemic growth in response to nutrition. The fat body …

The spatio-temporal regulation of gene expression determines the fate and function of
various cells and tissues and, as a consequence, the correct development and functioning of …

Homeostatic systems mount adaptive responses to meet the energy demands of the cell and
to compensate for dysfunction in cellular compartments. Such surveillance systems are also …

Nutrient-dependent body size plasticity differs between the sexes in most species, including
mammals. Previous work in Drosophila showed that body size plasticity was higher in …

Maintaining energy homeostasis is critical for ensuring proper growth and maximizing
survival potential of all organisms. Here we review the role of somatic muscle in regulating …

Health and survival in old age can be improved by changes in gene expression. RNA
polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre …