Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative
phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade …

Mitochondria are multifunctional subcellular organelles essential for cellular energy
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …

Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial
fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as …

Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response
(UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and …

Mutations in subunits of mitochondrial m-AAA proteases in the inner membrane cause
neurodegeneration in spinocerebellar ataxia (SCA28) and hereditary spastic paraplegia …

Resveratrol is a natural polyphenol found in various plants. It has been widely studied on
cardiovascular disorders. It is known that resveratrol can activate Sirtuin proteins and …

The lateral segregation of membrane constituents into functional microdomains,
conceptually known as lipid raft, is a universal organization principle for cellular membranes …

The cellular stress response (CSR) is pervasive to all domains of life. It has shaped the
interaction between organisms and their environment since the origin of the first cell …