Psoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic,
environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of …

Allergies are typically endemic, complex and heterogeneous diseases with a high impact at
quality of life. Mechanistically, type 2 immune responses involving eosinophil and basophil …

Research into the pathophysiology of psoriasis remains challenging, because this disease
does not occur naturally in laboratory animals. However, specific aspects of its complex …

Plasmacytoid dendritic cells (pDCs) are a professional type I IFN producer that play critical
roles in the pathogenesis of autoimmune diseases. However, both genetic regulation of the …

During the last decades, high-throughput assessment of gene expression in patient tissues
using microarray technology or RNA-Seq took center stage in clinical research. Insights into …

Objective To familiarize the reader with the mechanisms and causes of contact dermatitis.
Data Sources Recent research articles, relevant review articles, and case series/reports in …

Background Resident T cells are implicated in the maintenance and recurrence of psoriatic
lesions. Whether skin that has not yet experienced psoriasis in patients with established …

Autoimmune diseases are driven by either T cells or antibodies reacting specifically to 1 or
more self-antigens. Although a number of self-antigens associated with skin diseases have …

Mast cells are present in all vascularized tissues of the body. They are especially abundant
in tissues that are in frequent contact with the surrounding environment and act as potential …

Inflammatory response heterogeneity has impeded high-resolution dissection of diverse
immune cell populations during activation. We characterize mouse cutaneous immune cells …