Any spinal cord injury carries the potential for persistent disability affecting motor, sensory
and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of …

Understanding the pathophysiological changes triggered by an acute spinal cord injury is a
primary goal to prevent and treat chronic disability with a mechanism-based approach. After …

Kainate is an effective excitotoxic agent to lesion spinal cord networks, thus providing an
interesting model for investigating basic mechanisms of spinal cord injury. The present study …

While excitotoxicity is a major contributor to the pathophysiology of acute spinal injury, its
time course and the extent of cell damage in relation to locomotor network activity remain …

In vitro preparations of the neonatal rat spinal cord or brainstem are useful to investigate the
organization of motor networks and their dysfunction in neurological disease models. Long …

Recent improvements in organotypic slice culturing and its accompanying technological
innovations have made this biological preparation increasingly useful ex vivo experimental …

The secondary phase of spinal cord injury arising after the primary lesion largely extends the
damage severity with delayed negative consequences for sensory‐motor pathways. It is …

Kainate-mediated excitotoxicity of organotypic spinal cord cultures is an in vitro model
advantageous to investigate basic mechanisms of acute spinal injury and its …

Methylprednisolone sodium succinate (MPSS) has been proposed as a first-line treatment
for acute spinal cord injury (SCI). Its clinical use remains, however, controversial because of …

The postnatal rodent spinal cord in-vitro is a useful model to investigate early
pathophysiological changes after injury. While low dose nicotine (1 µM) induces …