Chromogranin A—biological function and clinical utility in neuro endocrine tumor disease

IM Modlin, BI Gustafsson, SF Moss, M Pavel… - Annals of surgical …, 2010 - Springer
Abstract Background Neuroendocrine tumors (NETs) are a form of cancer that differ from
other neoplasia in that they synthesize, store, and secrete peptides, eg, chromogranin A …

The extended granin family: structure, function, and biomedical implications

A Bartolomucci, R Possenti, SK Mahata… - Endocrine …, 2011 - academic.oup.com
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

Chromogranin A as circulating marker for diagnosis and management of neuroendocrine neoplasms: more flaws than fame

V Marotta, MC Zatelli, C Sciammarella… - Endocrine-related …, 2018 - erc.bioscientifica.com
Owing to the heterogeneity of neuroendocrine neoplasms (NENs), the availability of reliable
circulating markers is critical for improving diagnostics, prognostic stratification, follow-up …

Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation

SK Mahata, A Corti - Annals of the New York Academy of …, 2019 - Wiley Online Library
Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory
protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells …

The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors

B Lawrence, BI Gustafsson, M Kidd… - Endocrinology and …, 2011 - endo.theclinics.com
An accurate tumor marker is a critical tool in tumor management because it establishes an
uncertain diagnosis, offers a basis for individual prognostication, signals response to …

Biological function and clinical relevance of chromogranin A and derived peptides

MA D'amico, B Ghinassi, P Izzicupo… - Endocrine …, 2014 - ec.bioscientifica.com
Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with
catecholamines and can function as a pro-hormone by giving rise to several bioactive …

Chromogranin A: from laboratory to clinical aspects of patients with neuroendocrine tumors

P Di Giacinto, F Rota, L Rizza… - International Journal …, 2018 - Wiley Online Library
Background. Neuroendocrine tumors (NETs) are characterized by having behavior and
prognosis that depend upon tumor histology, primary site, staging, and proliferative index …

Circulating biomarkers in gastroenteropancreatic neuroendocrine tumours

K Oberg - Endocrine-related cancer, 2011 - erc.bioscientifica.com
The clinical presentation of gastroenteropancreatic neuroendocrine tumours (GEP-NETs)
varies according to the site and size of the primary tumour, the presence or absence of …

The Neuropeptide Catestatin Acts As a Novel Angiogenic Cytokine via a Basic Fibroblast Growth Factor–Dependent Mechanism

M Theurl, W Schgoer, K Albrecht, J Jeschke… - Circulation …, 2010 - Am Heart Assoc
Rationale: The neuropeptide catestatin is an endogenous nicotinic cholinergic antagonist
that acts as a pleiotropic hormone. Objective: Catestatin shares several functions with …

The emerging roles of chromogranins and derived polypeptides in atherosclerosis, diabetes, and coronary heart disease

T Watanabe - International Journal of Molecular Sciences, 2021 - mdpi.com
Chromogranin A (CgA), B (CgB), and C (CgC), the family members of the granin
glycoproteins, are associated with diabetes. These proteins are abundantly expressed in …