Regulation of biomolecular condensates by Poly (ADP-ribose)

K Rhine, HM Odeh, J Shorter, S Myong - Chemical reviews, 2023 - ACS Publications
Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …

[HTML][HTML] ADP-ribose contributions to genome stability, and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification

É Rouleau-Turcotte, JM Pascal - Journal of Biological Chemistry, 2023 - Elsevier
ABSTRACT ADP-ribose is a versatile modification that plays a critical role in diverse cellular
processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among …

Cation-induced intramolecular coil-to-globule transition in poly (ADP-ribose)

T Wang, K Coshic, M Badiee, MR McDonald… - Nature …, 2024 - nature.com
Abstract Poly (ADP-ribose)(PAR), a non-canonical nucleic acid, is essential for DNA/RNA
metabolism and protein condensation, and its dysregulation is linked to cancer and …

Divalent and multivalent cations control liquid-like assembly of poly (ADP-ribosyl) ated PARP1 into multimolecular associates in vitro

MV Sukhanova, RO Anarbaev, EA Maltseva… - Communications …, 2024 - nature.com
The formation of nuclear biomolecular condensates is often associated with local
accumulation of proteins at a site of DNA damage. The key role in the formation of DNA …

Positive selection analyses identify a single WWE domain residue that shapes ZAP into a more potent restriction factor against alphaviruses

S Huang, J Girdner, LAP Nguyen, C Sandoval… - Plos …, 2024 - journals.plos.org
The host interferon pathway upregulates intrinsic restriction factors in response to viral
infection. Many of them block a diverse range of viruses, suggesting that their antiviral …

[HTML][HTML] Phase Separation of FUS with Poly (ADP-ribosyl) ated PARP1 Is Controlled by Polyamines, Divalent Metal Cations, and Poly (ADP-ribose) Structure

MV Sukhanova, RO Anarbaev, KN Naumenko… - International Journal of …, 2024 - mdpi.com
Fused in sarcoma (FUS) is involved in the formation of nuclear biomolecular condensates
associated with poly (ADP-ribose)[PAR] synthesis catalyzed by a DNA damage sensor such …

Effects of poly (ADP‐ribose) polymerase 1 (PARP1) on silk proteins in the silkworm, Bombyx mori

M Wu, H Sun, A Wang, J Lao, D Liu… - Insect Molecular …, 2024 - Wiley Online Library
Animal silk is economically important, while silk secretion is a complex and subtle
mechanism regulated by many genes. We identified the poly (ADP‐ribose) polymerase …

The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors

A Beneyton, L Nonfoux, JP Gagné, A Rodrigue… - NAR …, 2023 - academic.oup.com
Abstract Poly (ADP-ribosylation)(PARylation) by poly (ADP-ribose) polymerases (PARPs) is
a highly regulated process that consists of the covalent addition of polymers of ADP-ribose …

Length-dependent Intramolecular Coil-to-Globule Transition in Poly (ADP-ribose) Induced by Cations

T Wang, K Coshic, M Badiee, A Aksimentiev, L Pollack… - bioRxiv, 2023 - biorxiv.org
Poly (ADP-ribose)(PAR), as part of a post-translational modification, serves as a flexible
scaffold for noncovalent protein binding. Such binding is influenced by PAR chain length …

[PDF][PDF] Biologically Relevant Polyamines, Divalent Metal Cations, and Structure of Poly (ADP-Ribose) All Control Microphase Separation of FUS with Poly (ADP …

MV Sukhanova, RO Anarbaev, KN Naumenko… - 2024 - preprints.org
Fused in sarcoma (FUS) is involved in the formation of nuclear biomolecular condensates
associated with poly (ADP-ribose)[PAR] synthesis catalyzed by a DNA damage sensor such …