The development of therapeutic resistance to targeted anticancer therapies remains a
significant clinical problem, with intratumoral heterogeneity playing a key role. In this context …

A multiscale tumour simulation model employing cell-line-specific biological parameters and
functional information derived from pre-therapy PET/CT imaging data was developed to …

Along with surgery and chemotherapy, radiotherapy is an effective way to treat cancer. Many
cancer patients take delivery of radiation. The goal of radiotherapy is to destroy the tumor …

Radiotherapy (RT) is among the regular techniques for the treatment of cancerous tumours.
Many of cancer patients are treated by this manner. Treatment planning is the most …

In this paper an advanced, clinically oriented multiscale cancer model of breast tumor
response to chemotherapy is presented. The paradigm of early breast cancer treated by …

Purpose: In radiotherapy, it is important to predict the response of tumors to irradiation prior
to the treatment. This is especially important for hypoxic tumors, which are known to be …

Computational models represent a highly suitable framework, not only for testing biological
hypotheses and generating new ones but also for optimising experimental strategies. As …

Critical Parameters Determining Standard Radiotherapy Treatment Outcome for Glioblastoma
Multiforme: A Computer Simulation - PMC Back to Top Skip to main content NIH NLM Logo …

The present paper aims at demonstrating clinically oriented applications of the multiscale
four dimensional in vivo tumor growth simulation model previously developed by our …

Radiobiological models of tumour control probability (TCP) can be personalized using
imaging data. We propose an extension to a voxel-level radiobiological TCP model in order …