Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this complex disorder of the …

The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

Signalling through the receptor protein Notch, which is involved in crucial cell-fate decisions
during development, requires ligand-induced cleavage of Notch. This cleavage occurs …

Development makes reiterative use of a surprisingly small set of essential molecular signals:
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …

Abstract γ-secretase-like proteolysis at site 3 (S3), within the transmembrane domain,
releases the Notch intracellular domain (NICD) and activates CSL-mediated Notch …

Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with
presenilin 1 and presenilin 2. Suppression of nicastrin expression in Caenorhabditis …

Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset
arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is …

▪ Abstract Intensive studies of three proteins—Presenilin, Notch, and the amyloid precursor
protein (APP)—have led to the recognition of a direct intersection between early …

Protein interaction mapping using large-scale two-hybrid analysis has been proposed as a
way to functionally annotate large numbers of uncharacterized proteins predicted by …

The amyloid β-peptide (Aβ) is a principal component of the cerebral plaques found in the
brains of patients with Alzeheimer's disease (AD). This insoluble 40–to 42–amino acid …