Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it
controls the correct segregation of chromosomes during mitosis. Many studies have focused …

For about a decade, poly [ADP ribose] polymerases (PARP) inhibitors have been used
almost exclusively to treat tumors that are deficient in one of the BRCA genes. In advanced …

Cancer-associated metastasis is the primary cause of morbidity and mortality. Yet, its
underlying biological mechanism remains poorly understood. Efforts to prevent or delay …

Accurate and complete DNA duplication is critical for maintaining genome integrity. Multiple
mechanisms regulate when and where DNA replication takes place, to ensure that the entire …

Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer
globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the …

Radioactivity is a process in which the nuclei of unstable atoms spontaneously decay,
producing other nuclei and releasing energy in the form of ionizing radiation in the form of …

Simple Summary For personalized oncology, it is crucial to develop appropriate patient-
derived tumor models that allow individualized validation of the most effective cancer …

Human exposures to rare earth elements are increasing with expanded use in aerospace,
precision instruments, and new energy batteries, materials, and fertilizers. Individually these …

Genomic instability is one of the hallmarks of cancer. While loss of histone demethylase
KDM6A increases the risk of tumorigenesis, its specific role in maintaining genomic stability …