Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

Fragment-based drug discovery (FBDD) is a powerful method to develop potent small-
molecule compounds starting from fragments binding weakly to targets. As FBDD exhibits …

Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle
network of protein interactions. The tumor suppressor protein p53 triggers transcription …

The accumulation of senescent cells is associated with aging, inflammation and cellular
dysfunction. Senolytic drugs can alleviate age-related comorbidities by selectively killing …

Overexpressed pro-survival B-cell lymphoma-2 (BCL-2) family proteins BCL-2 and BCL-XL
can render tumor cells malignant. Leukemia drug venetoclax is currently the only approved …

Fragment-based drug discovery (FBDD) has grown and matured to a point where it is
valuable to keep track of its extent and details of application. This Perspective summarizes …

Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is
an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human …

Protein–protein interactions (PPIs) control many important physiological processes within
human cells. Apoptosis or programmed cell death is closely regulated by pro-and …

Myeloid cell leukemia‐1 (MCL1), an antiapoptotic member of the BCL2 family characterized
by a short half‐life, functions as a rapid sensor that regulates cell death and other relevant …

Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins,
whose upregulation when observed in human cancers is associated with high tumor grade …