Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine
Q Yao, S Cheng, Q Pan, J Yu, G Cao, L Li, H Cao - MedComm, 2024 - Wiley Online Library
Organoids are miniature, highly accurate representations of organs that capture the structure
and unique functions of specific organs. Although the field of organoids has experienced …
and unique functions of specific organs. Although the field of organoids has experienced …
Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes
J Chen, XL Yuan, X Zhou, J Xu, X Zhang, X Duan - Clinical Epigenetics, 2024 - Springer
Background Age-related eye diseases (AREDs) have become increasingly prevalent with
the aging population, serving as the leading causes of visual impairment worldwide …
the aging population, serving as the leading causes of visual impairment worldwide …
[HTML][HTML] The application of retinal organoids in ophthalmic regenerative medicine: A mini-review
X Lan, H Jiang, Q Wang, Q Shiqi, Y Xiong - Regenerative Therapy, 2024 - Elsevier
Retinal organoids are three-dimensional (3D) microscopic tissues that are induced and
differentiated from stem cells or progenitor cells in vitro and have a highly similar structure to …
differentiated from stem cells or progenitor cells in vitro and have a highly similar structure to …
[HTML][HTML] Animal models of human disease 2.0
The use of animal models is crucial for advancing translational research by identifying and
validating effective treatment targets and strategies for clinical application in human disease …
validating effective treatment targets and strategies for clinical application in human disease …
Green synthesis of neuroprotective spirocyclic chalcone derivatives and their role in protecting against traumatic optic nerve injury
J Wu, M Han, X Tan, L Zeng, Z Yang, H Zhong… - European Journal of …, 2024 - Elsevier
For clinically prevalent traumatic optic neuropathy (TON) and other retinal and optic nerve
injuries lacking effective therapeutic agents, there is an urgent clinical demand for …
injuries lacking effective therapeutic agents, there is an urgent clinical demand for …
[HTML][HTML] Dexamethasone Impairs ATP Production and Mitochondrial Performance in Human Trabecular Meshwork Cells
S Kennedy, C Williams, E Tsaturian… - Current Issues in …, 2024 - mdpi.com
Mitochondrial damage occurs in human trabecular meshwork (HTM) cells as a result of
normal aging and in open angle glaucoma. Using an HTM cell model, we quantified …
normal aging and in open angle glaucoma. Using an HTM cell model, we quantified …
Restoring and sustaining human postmortem retinal light responses with scalable methods for testing degenerative disease therapies
S Becker, J Allen, Z L'Ecuyer Morison, S Saeid… - bioRxiv, 2024 - biorxiv.org
Neuro-and retinal degenerative diseases rob millions of aging individuals of their
independence. Researching these diseases in human tissue has been hindered by the …
independence. Researching these diseases in human tissue has been hindered by the …
All eyes on the spiny mouse: an investigation into Acomys dimidiatus as a model for retinal biology and regeneration
JD Bills - uknowledge.uky.edu
The retina is a complex tissue with six types of neurons, supported by an intrinsic glia cell,
that work in concert to input a visual stimulus and relay a visual message to the brain …
that work in concert to input a visual stimulus and relay a visual message to the brain …