The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …

Myeloid-derived suppressor cells (MDSCs) are one of the most discussed biological entities
in immunology. While the context and classification of this group of cells has evolved …

Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune
escape, and their functions are regulated by multiple epigenetic mechanisms. The precise …

Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …

Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict
immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance …

Aerobic exercise is associated with decreased cancer incidence and cancer-associated
mortality. However, little is known about the effects of exercise on pancreatic ductal …

Neutrophils are the frontline cells in response to microbial infections and are involved in a
range of inflammatory disorders in the body. In recent years, neutrophils have gained …

Immune checkpoint inhibitor (ICI) therapy is effective against many cancers for a subset of
patients; a large percentage of patients remain unresponsive to this therapy. One …

Tumor cells promote the recruitment of immunosuppressive neutrophils, a subset of myeloid
cells driving immune suppression, tumor proliferation, and treatment resistance …