Abstract Purpose For over 50 years, 5-FU has played a critical role in the systemic
chemotherapy of cancer patients. 5-FU serves as the main backbone of combination …

Doxorubicin (DOX), a widely used drug in cancer chemotherapy, induces cell death via
multiple intracellular interactions, generating reactive oxygen species and DNA-adducted …

Purpose To report the results of a planned safety analysis from a phase III trial comparing
capecitabine plus oxaliplatin (XELOX) with bolus fluorouracil/leucovorin (FU/LV) as adjuvant …

The use of oral anticancer drugs has shown a steady increase. Most patients prefer
anticancer oral therapy to intravenous treatment primarily for the convenience of a home …

Cancer patients experienced an increased risk of cardiotoxicity during fluoropyrimidine-
based chemotherapy (5-fluorouracil or capecitabine). We searched PubMed, PsycINFO, IPA …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death in industrialized countries. Chemoprevention is a promising approach …

Traditionally, anticancer therapy has been dominated by intravenous drug therapy.
However, oral agents provide an attractive approach to chemotherapy and use of oral …

A rapidly growing number of oral anticancer agents has become available in oncology and
hematology. Though these introductions have several benefits, medication adherence is an …

5-Fluorouracil has been a mainstay in the treatment of colorectal cancer for nearly five
decades; however, the use of oral formulations of the medication has been gaining …

Historically, most of anticancer drugs were delivered by the intravenous route which is the
most direct one leading to immediate and complete bioavailability of the drugs. However …