Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies

K Ulbrich, K Hola, V Subr, A Bakandritsos… - Chemical …, 2016 - ACS Publications
Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …

Antibody‐incorporated nanomedicines for cancer therapy

SY Wu, FG Wu, X Chen - Advanced Materials, 2022 - Wiley Online Library
Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …

David vs. Goliath: the structure, function, and clinical prospects of antibody fragments

A Bates, CA Power - Antibodies, 2019 - mdpi.com
Since the licensing of the first monoclonal antibody therapy in 1986, monoclonal antibodies
have become the largest class of biopharmaceuticals with over 80 antibodies currently …

Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy.

M Xuan, J Shao, L Dai, Q He, J Li - Advanced healthcare materials, 2015 - europepmc.org
Engineering natural macrophage cell membrane-camouflaged mesoporous silica
nanocapsules can reduce the arrested percentage of immune cells and tissues, effectively …

HPMA copolymers: origins, early developments, present, and future

J Kopeček, P Kopečková - Advanced drug delivery reviews, 2010 - Elsevier
The overview covers the discovery of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers, initial studies on their synthesis, evaluation of biological properties, and …

Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer

GY Lee, WP Qian, L Wang, YA Wang, CA Staley… - ACS …, 2013 - ACS Publications
The tumor stroma in human cancers significantly limits the delivery of therapeutic agents into
cancer cells. To develop an effective therapeutic approach overcoming the physical barrier …

Hydrogels for pharmaceutical and biomedical applications

N Kashyap, N Kumar… - Critical Reviews™ in …, 2005 - dl.begellhouse.com
Hydrogels are crosslinked hydrophilic polymer structures that can imbibe large amounts of
water or biological fluids. Hydrogels are one of the upcoming classes of polymer-based …

Recent advances in nanomicelles delivery systems

SM Tawfik, S Azizov, MR Elmasry, M Sharipov, YI Lee - Nanomaterials, 2020 - mdpi.com
The efficient and selective delivery of therapeutic drugs to the target site remains the main
obstacle in the development of new drugs and therapeutic interventions. Up until today …

Drug targeting using thermally responsive polymers and local hyperthermia

DE Meyer, BC Shin, GA Kong, MW Dewhirst… - Journal of controlled …, 2001 - Elsevier
We report a new thermal targeting method in which a thermally responsive drug carrier
selectively accumulates in a solid tumor that is maintained above physiological temperature …

HPMA copolymer–anticancer drug conjugates: design, activity, and mechanism of action

J Kopeček, P Kopečková, T Minko, ZR Lu - European journal of …, 2000 - Elsevier
The design, synthesis and properties of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …