J Lobo, AJM Gillis, C Jerónimo, R Henrique… - International journal of …, 2019 - mdpi.com
Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead through a defined locked …
KP Dieckmann, A Radtke, M Spiekermann, T Balks… - European urology, 2017 - Elsevier
Background Clinical management of germ cell tumours (GCTs) relies on monitoring of serum tumour markers. However, the markers α-fetoprotein (AFP), the β-subunit of human …
MJ Murray, RA Huddart, N Coleman - Nature Reviews Urology, 2016 - nature.com
Testicular germ cell tumours (GCTs) are the most common malignancy occurring in young adult men and the incidence of these tumours is increasing. Current research priorities in …
I Syring, J Bartels, S Holdenrieder… - The Journal of …, 2015 - auajournals.org
Purpose: Classic serum tumor markers (human chorionic gonadotropin, α1-fetoprotein and lactate dehydrogenase) have an important role in managing testicular germ cell tumor …
Testicular germ cell tumours (TGCTs) are the most frequent cancer type in young men and originate from the common precursor germ cell neoplasia in situ (GCNIS). For decades …
J Lobo, AJM Gillis, A van den Berg, LCJ Dorssers… - Cells, 2019 - mdpi.com
Liquid biopsy-based biomarkers, such as microRNAs, represent valuable tools for patient management, but often do not make it to integration in the clinic. We aim to explore issues …
MJ Murray, E Bell, KL Raby, MA Rijlaarsdam… - British journal of …, 2016 - nature.com
Background: The current biomarkers alpha-fetoprotein and human chorionic gonadotropin have limited sensitivity and specificity for diagnosing malignant germ-cell tumours (GCTs) …
KP Dieckmann, M Spiekermann, T Balks, I Flor… - British journal of …, 2012 - nature.com
Background: miRNAs are small noncoding RNA molecules that can be released into body fluids. Germ cell tumours (GCTs) overexpress miRNAs of the miR-371-3 cluster. Thus, serum …
AJM Gillis, MA Rijlaarsdam, R Eini, LCJ Dorssers… - Molecular …, 2013 - Elsevier
Germ cell cancers (GCC) are the most frequent malignancy in young Caucasian males. GCC can consist of seminomas (SE) and non-seminomas (malignant NS: embryonal …