Vascular mechanotransduction

MJ Davis, S Earley, YS Li, S Chien - Physiological reviews, 2023 - journals.physiology.org
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Endothelial shear stress signal transduction and atherogenesis: from mechanisms to therapeutics

L He, CL Zhang, Q Chen, L Wang, Y Huang - Pharmacology & therapeutics, 2022 - Elsevier
Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation

L Zhong, MJ Simard, J Huot - The FASEB Journal, 2018 - Wiley Online Library
The surface of endothelial cells is covered with cell adhesion molecules, including E‐
selectin, intercellula adhesion molecule 1 (ICAM‐1), and vascular cell adhesion molecule 1 …

The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease

DA Chistiakov, AN Orekhov, YV Bobryshev - Journal of molecular and …, 2016 - Elsevier
Abstract Expression of microRNA (miR)-126 is enriched in endothelial cells (ECs) and
endothelial progenitor cells (EPCs). MiR-126 is considered a master regulator of …

Molecular effects of exercise training in patients with cardiovascular disease: focus on skeletal muscle, endothelium, and myocardium

V Adams, B Reich, M Uhlemann… - American Journal of …, 2017 - journals.physiology.org
For decades, we have known that exercise training exerts beneficial effects on the human
body, and clear evidence is available that a higher fitness level is associated with a lower …

Oxidative stress in chronic vascular disease: from prediction to prevention

F Santilli, D D'Ardes, G Davi - Vascular pharmacology, 2015 - Elsevier
This review article is intended to describe the strong relationship between oxidative stress
and vascular disease. Reactive oxygen species (ROS) play an important role in the …

Circulating microRNAs in acute and chronic exercise: more than mere biomarkers

RM Sapp, DD Shill, SM Roth… - Journal of Applied …, 2017 - journals.physiology.org
MicroRNAs (miRNAs) are short, noncoding RNAs that influence biological processes by
regulating gene expression after transcription. It was recently discovered that miRNAs are …

[HTML][HTML] Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function

D Pretorius, RP Richter, T Anand, JC Cardenas… - Matrix Biology Plus, 2022 - Elsevier
The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network
of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular …

S100A12 promotes inflammation and cell apoptosis in sepsis-induced ARDS via activation of NLRP3 inflammasome signaling

N Han, Y Shen - Molecular immunology, 2020 - Elsevier
Sepsis is a multiple organ dysfunction elicited by the dysregulated host immune response to
microbial infection. Acute respiratory distress syndrome (ARDS) is a serious and acute …

Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA

JB Tryggestad, A Vishwanath, S Jiang… - Clinical …, 2016 - portlandpress.com
We aimed to identify miRNAs whose expression levels in fetal tissues are altered by
exposure to a diabetic milieu and elucidate the impact on target protein expression …