Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma

A Poff, AP Koutnik, KM Egan, S Sahebjam… - Seminars in Cancer …, 2019 - Elsevier
Gliomas are a highly heterogeneous tumor, refractory to treatment and the most frequently
diagnosed primary brain tumor. Although the current WHO grading system (2016) …

Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation

RJ Klement - Medical Oncology, 2017 - Springer
Ketogenic diets (KDs) have gained popularity among patients and researchers alike due to
their putative anti-tumor mechanisms. However, the question remains which conclusions …

[HTML][HTML] Ketogenic diets for adult neurological disorders

TJW McDonald, MC Cervenka - Neurotherapeutics, 2018 - Elsevier
The current review highlights the evidence supporting the use of ketogenic diet therapies in
the management of a growing number of neurological disorders in adults. An overview of the …

Autophagy as a potential therapy for malignant glioma

A Escamilla-Ramírez, RA Castillo-Rodríguez… - Pharmaceuticals, 2020 - mdpi.com
Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic
astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival …

The expanding role of ketogenic diets in adult neurological disorders

TJW McDonald, MC Cervenka - Brain sciences, 2018 - mdpi.com
The current review highlights the evidence supporting the use of ketogenic diet therapies in
the management of adult epilepsy, adult malignant glioma and Alzheimer's disease. An …

Role of ketogenic metabolic therapy in malignant glioma: a systematic review

SF Winter, F Loebel, J Dietrich - Critical reviews in oncology/hematology, 2017 - Elsevier
Abstract Background Coined as the “Warburg effect” and a recognized hallmark of cancer,
energy metabolism is aberrantly geared towards aerobic glycolysis in most human cancers …

Steroids use and survival in patients with glioblastoma multiforme: a pooled analysis

F Petrelli, A De Stefani, A Ghidini, L Bruschieri… - Journal of …, 2021 - Springer
Introduction Steroids are commonly used for managing brain edema in patients with
glioblastoma multiforme (GBM), treated with surgery and concomitant temozolomide-based …

The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy …

AA Stepanenko, AO Sosnovtseva, MP Valikhov… - Frontiers in …, 2024 - frontiersin.org
Despite significant advances in our knowledge regarding the genetics and molecular
biology of gliomas over the past two decades and hundreds of clinical trials, no effective …

Could Metformin and Resveratrol Support Glioblastoma Treatment? A Mechanistic View at the Cellular Level

RS Ibrahim, SS Ibrahim, A El-Naas, L Koklesová… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma's poor prognosis calls for the discovery of newer, more
efficacious management and treatment methods. This review collates and examines how the …

Frontiers in anti-cancer drug discovery: Challenges and perspectives of metformin as anti-angiogenic add-on therapy in glioblastoma

L Guarnaccia, G Marfia, MM Masseroli, SE Navone… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma is the most aggressive primary brain tumor, with the highest
incidence and the worst prognosis. Life expectancy from diagnosis remains dismal, at …