The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …

The multiple functions of lysosomes are critically dependent on their ability to undergo
bidirectional movement along microtubules between the center and the periphery of the cell …

Neurons relay information via specialized presynaptic compartments for neurotransmission.
Unlike conventional organelles, the specialized apparatus characterizing the neuronal …

The expansion of the neocortex during mammalian brain evolution results primarily from an
increase in neural progenitor cell divisions in its two principal germinal zones during …

Although neuronal subtypes display unique synaptic organization and function, the
underlying transcriptional differences that establish these features are poorly understood. To …

Nervous system function relies on the polarized architecture of neurons, established by
directional transport of pre-and postsynaptic cargoes. While delivery of postsynaptic …

Autophagy, a lysosome-dependent degradation mechanism, mediates many biological
processes, including cellular stress responses and neuroprotection. In this study, we …

Intracellular transport is typically bidirectional, consisting of a series of back and forth
movements. Kinesin-1 and cytoplasmic dynein require each other for bidirectional transport …

Neurons are highly polarized cells with a single axon and multiple dendrites derived from
the cell body to form tightly associated pre-and postsynaptic compartments. As the …