Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

The plasma membrane, which encapsulates human cells, is composed of a complex mixture
of lipids and embedded proteins. Emerging knowledge points towards the lipids as having a …

Numerous studies demonstrated that membrane cholesterol is a major regulator of ion
channel function. The goal of this review is to discuss significant advances that have been …

As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …

Ion transport across cell membranes is essential to cell communication and signaling.
Passive ion transport is mediated by ion channels, membrane proteins that create ion …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

Cholesterol decreases the activity of the majority of ion channels while increasing the activity
of only a few, yet it remains unclear how. Here, we used the inwardly rectifying potassium …

The impact of cholesterol on the structure and function of membrane proteins was
recognized several decades ago, but the molecular mechanisms underlying these effects …

This review summarizes the current status and recent advances in our understanding of the
role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease …