Aplastic anemia (AA) and hypoplastic myelodysplastic syndrome are paradigms of
autoimmune hematopoietic failure (AHF). Myelodysplastic syndrome and acute myeloid …

Abnormal activation of the immune system plays an important role in the pathogenesis of
aplastic anemia (AA). Various immune cells and cytokines constitute a complex immune …

Prior research has identified associations between immune cells and aplastic anaemia (AA);
however, the causal relationships between them have not been conclusively established. A …

Accumulating evidence has revealed that human gingiva-derived mesenchymal stem cells
(GMSCs) are emerging as a new line of mesenchymal stem cells and may have the potential …

Key Points Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow
aplasia, without a known etiologic trigger. Clonal expansion of CD8+ effector T lymphocytes …

Pyruvate kinase (PK) is a key enzyme that catalyzes the dephosphorylation of
phosphoenolpyruvate (PEP) into pyruvate, and is responsible for the production of ATP …

Objective: The aim of this study was to analyze T-lymphocyte subsets and Th1/Th2 cytokines
in convalescent patients with Epstein–Barr virus (EBV)-associated aplastic anemia (AA) …

Background Natural killer (NK) cells play important immunoregulatory roles in the immune
pathogenesis of severe aplastic anemia (SAA). Our previous research showed that SAA …

Idiopathic aplastic anemia (AA) has 2 key characteristics: an autoimmune response against
hematopoietic stem/progenitor cells and regulatory T-cells (Tregs) deficiency. We have …

Aplastic anemia (AA) is an auto-activated T cell–mediated bone marrow failure.
Cyclosporine is often used to treat non-severe AA, which demonstrates a more …