Fungi, usually present as commensals, are a major cause of opportunistic infections in
immunocompromised patients. Such infections, if not diagnosed or treated properly, can …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

Genotyping microarrays are an important resource for genetic mapping, population genetics,
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …

Conclusions: ARRB1 up‐regulates the release of hepatocyte‐derived MASP1‐enriched
small EVs by regulating the autophagic‐lysosomal/multivesicular body pathway and …

Mannose-binding lectin (MBL) is a pattern recognition protein that plays an important role in
innate immunity capable of activating the lectin pathway of the complement system. In this …

The complement system is an important part of the innate and adaptive immune systems.
Originally characterized as a single serum component contributing to the killing of bacteria …

Components of the complement system and atypical parameters of coagulation were
reported in COVID-19 patients, as well as the exacerbation of the inflammation and …

Background Nanoparticle (NP)–based vaccines are attractive immunotherapy tools because
of their capability to codeliver antigen and adjuvant to antigen-presenting cells. Their cellular …

Mannose-binding lectin-associated serine protease 2 (MASP-2) is the main activator of the
lectin complement pathway and has been suggested to be involved in the pathophysiology …

It had been thought that complement factor D (FD) is activated at the site of synthesis, and
only FD lacking a propeptide is present in blood. The serum of mannose-binding lectin …