Hydrogels for RNA delivery

R Zhong, S Talebian, BB Mendes, G Wallace… - Nature materials, 2023 - nature.com
RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …

Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Polymer-based hydrogels applied in drug delivery: An overview

NH Thang, TB Chien, DX Cuong - Gels, 2023 - mdpi.com
Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied
for drug delivery applications because of their ability to hold large amounts of water and …

Nanogels: Synthesis, properties, and recent biomedical applications

QY Duan, YX Zhu, HR Jia, SH Wang, FG Wu - Progress in Materials …, 2023 - Elsevier
Nanogels, also termed hydrogel nanoparticles, have the properties and functions of both
nanomaterials and hydrogels. Till date, a considerable number of nanogels have been …

Harnessing endogenous stimuli for responsive materials in theranostics

AB Cook, P Decuzzi - ACS nano, 2021 - ACS Publications
Materials that respond to endogenous stimuli are being leveraged to enhance
spatiotemporal control in a range of biomedical applications from drug delivery to diagnostic …

Hydrogels as functional components in artificial cell systems

ME Allen, JW Hindley, DK Baxani, O Ces… - Nature Reviews …, 2022 - nature.com
Recent years have seen substantial efforts aimed at constructing artificial cells from various
molecular components with the aim of mimicking the processes, behaviours and …

Analyte-responsive hydrogels: intelligent materials for biosensing and drug delivery

HR Culver, JR Clegg, NA Peppas - Accounts of chemical …, 2017 - ACS Publications
Conspectus Nature has mastered the art of molecular recognition. For example, using
synergistic non-covalent interactions, proteins can distinguish between molecules and bind …

[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy

Q Xiao, X Li, Y Li, Z Wu, C Xu, Z Chen, W He - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …

Ligand‐dependent activity engineering of glutathione peroxidase‐mimicking MIL‐47 (V) metal–organic framework nanozyme for therapy

J Wu, Y Yu, Y Cheng, C Cheng, Y Zhang… - Angewandte …, 2021 - Wiley Online Library
Glutathione peroxidase (GPx) plays an important role in maintaining the reactive oxygen
metabolic balance, yet limited GPx‐mimicking nanozymes are currently available for in vivo …

Bioinspired Spatiotemporal Management toward RNA Therapies

Y Ma, S Li, X Lin, Y Chen - ACS nano, 2023 - ACS Publications
Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …