Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in
hematologic malignancies, but its application to solid tumors has proven challenging. This …

Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …

Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of
CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced …

Abstract Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated
with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis …

Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC)
differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is …

Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Although elevated plasma interleukin-8 (pIL-8) has been associated with poor outcome to
immune checkpoint blockade, this has not been comprehensively evaluated in large …

Simple Summary This review focuses on the pro-tumorigenic action of neutrophil
extracellular traps (NETs). NETs were found in various samples of human and animal …

CD4+ T cells that recognize tumor antigens are required for immune checkpoint inhibitor
efficacy in murine models, but their contributions in human cancer are unclear. We used …