Proteomic and metabolomic correlates of healthy dietary patterns: the Framingham Heart Study

ME Walker, RJ Song, X Xu, RE Gerszten, D Ngo… - Nutrients, 2020 - mdpi.com
Data on proteomic and metabolomic signatures of healthy dietary patterns are limited. We
evaluated the cross-sectional association of serum proteomic and metabolomic markers with …

Bioinformatics analysis of vascular RNA-seq data revealed hub genes and pathways in a novel Tibetan minipig atherosclerosis model induced by a high fat …

Y Pan, C Yu, J Huang, Y Rong, J Chen… - Lipids in Health and …, 2020 - Springer
Background Atherosclerosis is a major contributor to cardiovascular events, however, its
molecular mechanism remains poorly known. Animal models of atherosclerosis can be a …

Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques–Tampere Vascular Study

M Sulkava, E Raitoharju, M Levula, I Seppälä… - Scientific Reports, 2017 - nature.com
Cardiovascular diseases due to atherosclerosis are the leading cause of death globally. We
aimed to investigate the potentially altered gene and pathway expression in advanced …

IGFBP6 is downregulated in unstable carotid atherosclerotic plaques according to an integrated bioinformatics analysis and experimental verification

Y Liu, W Huan, J Wu, S Zou, L Qu - Journal of Atherosclerosis and …, 2020 - jstage.jst.go.jp
Aims: To investigate the differentially expressed genes (DEGs) and molecular interaction in
unstable atherosclerotic carotid plaques. Methods: Gene expression datasets GSE41571 …

Comprehensive analysis of immunocyte infiltration and the key genes associated with intraplaque hemorrhage in carotid atherosclerotic plaques

S Li, Q Zhang, Z Huang, W Tao, C Zeng, L Yan… - International …, 2022 - Elsevier
Purpose To identify key biomarkers associated with intraplaque hemorrhage (IPH). Methods
We conducted a comprehensive analysis combined with DEGs, xCell, WGCNA, GSEA, and …

GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis

D Tsukui, Y Kimura, H Kono - Iscience, 2023 - cell.com
Atherosclerosis complicates chronic inflammatory diseases, such as rheumatoid arthritis and
systemic lupus erythematosus, suggesting that a shared physiological pathway regulates …

Do neutrophil extracellular traps implicate in atheromatous plaques from carotid endarterectomy? Re-analyzes of cDNA microarray data by surgeons

R Takahira, K Ujifuku, T Izumo, A Xie… - Frontiers in …, 2023 - frontiersin.org
Background Carotid artery stenosis is the cause of 15% of strokes. Neutrophil extracellular
traps (NETs) and peptidyl arginine deiminase 4 (PAD4) are believed to be involved in …

Identification of immune infiltration-related biomarkers in carotid atherosclerotic plaques

K Zheng, W Yang, S Wang, M Sun, Z Jin, W Zhang… - Scientific Reports, 2023 - nature.com
Atherosclerosis is a chronic lipid-driven inflammatory response of the innate and adaptive
immune systems, and it is responsible for several cardiovascular ischemic events. The …

A computational method of defining potential biomarkers based on differential sub-networks

X Huang, X Lin, J Zeng, L Wang, P Yin, L Zhou, C Hu… - Scientific Reports, 2017 - nature.com
Analyzing omics data from a network-based perspective can facilitate biomarker discovery.
To improve disease diagnosis and identify prospective information indicating the onset of …

Microarray profiling of miRNA and mRNA expression in Rag2 knockout and wild-type mouse spleens

AMMT Reza, SK Cho, YJ Choi, K Hong, JH Kim - Scientific Data, 2018 - nature.com
The Rag2 knockout (KO) mouse is one of the most popular immune compromised animal
models used in biomedical research. The immune compromised state concurrently alters …