Metabolite identification (Met ID) is important during the early stages of drug discovery and
development, as the metabolic products may be pharmacologically active or toxic in nature …

Metabolism studies play a pivotal role in drug discovery and development. Characterization
of metabolic “hotspots” as well as reactive and pharmacologically active metabolites is …

The only comprehensive guide to CIMS applications in structural elucidation and analytical
studiesChemical Ionization Mass Spectrometry, 2nd Edition, provides a comprehensive, up …

Ions with a short residence time were observed with an API (atmospheric pressure
ionization) corona discharge source by locating the discharge point 0.5 mm from the …

A new method is described for performing hydrogen/deuterium (H/D) exchange in an
electrospray ionization (ESI) source. The use of liquid chromatography (LC)-mass …

Ion/molecule reactions are described which facilitate exchange of hydrogens for deuteriums
in a variety of different chemical environments. Aromatic hydrogens in alkylbenzenes …

The combined use of hydrogen/deuterium exchange (HDX) and mass spectrometry (MS),
referred to as HDX‐MS, is a powerful tool for exploring molecular edifices and has been …

Electrospray ionization (ESI) and collisionally induced dissociation (CID) mass spectra were
obtained for five tetracyclines and the corresponding compounds in which the labile …

We report here for the first time the application of atmospheric pressure photo ionization
hydrogen/deuterium exchange (APPI HDX) coupled to high-resolution mass spectrometry …

A systematic study was performed to investigate the utility of atmospheric pressure chemical
ionization hydrogen–deuterium exchange mass spectrometry (APCI HDX MS) to identify the …