At present, the great challenge in human genetics is to provide significance to the growing
amount of human disease-associated gene variants identified by next generation DNA …

Ribosome biogenesis is one of the most energy demanding processes in the cell. In
eukaryotes, the main steps of this process occur in the nucleolus and include pre-ribosomal …

ABSTRACT COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) has had a devastating impact on global public health, emphasizing the …

Hutchinson–Gilford progeria syndrome (HGPS), commonly called progeria, is an extremely
rare disorder that affects only one child per four million births. It is characterized by …

The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and
longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the …

Simple Summary Canine diabetes is a serious disease, which can lead to severe
complications, eventually even death. Currently, all the diagnostic procedures are the …

Human ZMPSTE24, an integral membrane zinc metalloprotease, is required for conversion
of prelamin A to mature lamin A, a component of the nuclear lamina and failure of this …

Protein and peptide prenylation is an essential biological process involved in many signal
transduction pathways. In its most prevalent form, prenylation involves three enzymatic …

The yeast zinc metalloprotease, Ste24, is involved in the maturation of the yeast mating
pheromone a-factor by performing two distinct cleavages in the same precursor peptide …

Several related progeroid disorders are caused by defective post-translational processing of
prelamin A, the precursor of the nuclear scaffold protein lamin A, encoded by LMNA …