Pathogenesis of pneumonia and acute lung injury

ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

IL-17 and IL-17-producing cells in protection versus pathology

KHG Mills - Nature Reviews Immunology, 2023 - nature.com
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

A Janus-Faced Bacterium: Host-Beneficial and -Detrimental Roles of Cutibacterium acnes

H Brüggemann, L Salar-Vidal, HPM Gollnick… - Frontiers in …, 2021 - frontiersin.org
The bacterial species Cutibacterium acnes (formerly known as Propionibacterium acnes) is
tightly associated with humans. It is the dominant bacterium in sebaceous regions of the …

Neutrophil extracellular traps promote NLRP3 inflammasome activation and glomerular endothelial dysfunction in diabetic kidney disease

A Gupta, K Singh, S Fatima, S Ambreen… - Nutrients, 2022 - mdpi.com
Diabetes mellitus is a metabolic disease largely due to lifestyle and nutritional imbalance,
resulting in insulin resistance, hyperglycemia and vascular complications. Diabetic kidney …

Neutrophil extracellular traps: New players in cancer research

J Zhao, J Jin - Frontiers in immunology, 2022 - frontiersin.org
NETs are chromatin-derived webs extruded from neutrophils as a result of either infection or
sterile stimulation using chemicals, cytokines, or microbes. In addition to the classical role …

Extracellular DNA traps: Origin, function and implications for anti-cancer therapies

M Mamtimin, A Pinarci, C Han, A Braun… - Frontiers in …, 2022 - frontiersin.org
Extracellular DNA may serve as marker in liquid biopsies to determine individual diagnosis
and prognosis in cancer patients. Cell death or active release from various cell types …

Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis

AA Joshi, M Vocanson, JF Nicolas, P Wolf… - Frontiers in …, 2023 - frontiersin.org
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly
affects the patient's quality of life. A disrupted skin barrier, type 2 cytokine-dominated …

Treatment response to isotretinoin correlates with specific shifts in Cutibacterium acnes strain composition within the follicular microbiome

ZT Nolan, K Banerjee, Z Cong, SL Gettle… - Experimental …, 2023 - Wiley Online Library
There are no drugs as effective as isotretinoin for acne. Deciphering the changes in the
microbiome induced by isotretinoin in the pilosebaceous follicle of successfully treated …

Yin and Yang: A disrupted skin microbiome and an aberrant host immune response in hidradenitis suppurativa

SL Schell, AM Schneider… - Experimental …, 2021 - Wiley Online Library
The skin microbiome plays an important role in maintaining skin homeostasis by controlling
inflammation, providing immune education and maintaining host defense. However, in many …

Association of different cell types and inflammation in early acne vulgaris

L Huang, S Yang, X Yu, F Fang, L Zhu, L Wang… - Frontiers in …, 2024 - frontiersin.org
Acne vulgaris, one of the most common skin diseases, is a chronic cutaneous inflammation
of the upper pilosebaceous unit (PSU) with complex pathogenesis. Inflammation plays a …