DYRK1A inhibitors for disease therapy: Current status and perspectives
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …
protein kinase that plays essential roles in various biological processes. It is located in the …
Function and inhibition of DYRK1A: emerging roles of treating multiple human diseases
Y Yang, X Fan, Y Liu, D Ye, C Liu, H Yang, Z Su… - Biochemical …, 2023 - Elsevier
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …
Visible-light-initiated malic acid-promoted cascade coupling/cyclization of aromatic amines and KSCN to 2-aminobenzothiazoles without photocatalyst
WB He, LQ Gao, XJ Chen, ZL Wu, Y Huang… - Chinese Chemical …, 2020 - Elsevier
By using ambient air as the oxidant and malic acid as the promoter, a practical method for
the preparation of 2-aminobenzothiazoles through visible-light-initiated cascade reaction of …
the preparation of 2-aminobenzothiazoles through visible-light-initiated cascade reaction of …
Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer's disease
DE Hafez, M Dubiel, G La Spada, M Catto… - Journal of Enzyme …, 2023 - Taylor & Francis
Neurodegenerative diseases such as Alzheimer's disease (AD) are multifactorial with
several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed …
several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed …
Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects
A role of Dyrk1A in the progression of Down syndrome–related Alzheimer's disease (AD) is
well supported. However, the involvement of Dyrk1A in the pathogenesis of Parkinson's …
well supported. However, the involvement of Dyrk1A in the pathogenesis of Parkinson's …
A review on synthetic inhibitors of dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) for the treatment of Alzheimer's disease (AD)
Alzheimer's disease (AD) is a complex disorder that is influenced by a number of variables,
such as age, gender, environmental factors, disease, lifestyle, infections, and many more …
such as age, gender, environmental factors, disease, lifestyle, infections, and many more …
Discovery of hydroxybenzothiazole urea compounds as multitargeted agents suppressing major cytotoxic mechanisms in neurodegenerative diseases
Multiple factors are causally responsible and/or contribute to the progression of Alzheimer's
and Parkinson's diseases. The protein kinase Dyrk1A was identified as a promising target as …
and Parkinson's diseases. The protein kinase Dyrk1A was identified as a promising target as …
Synthesis and Biological Importance of 2-(thio) ureabenzothiazoles
MC Rosales-Hernández, JE Mendieta-Wejebe… - Molecules, 2022 - mdpi.com
The (thio) urea and benzothiazole (BT) derivatives have been shown to have a broad
spectrum of biological activities. These groups, when bonded, result in the 2-(thio) …
spectrum of biological activities. These groups, when bonded, result in the 2-(thio) …
Dual targeting of inflammation and β-cell dysfunction for therapy of diabetes mellitus
F Mustafa, M Abdel-Halim, R Abdel-Moniem… - Journal of Drug Delivery …, 2024 - Elsevier
Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by β-cell loss and
inflammation. From a therapeutic standpoint, it would be necessary to halt the uncontrolled …
inflammation. From a therapeutic standpoint, it would be necessary to halt the uncontrolled …
Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimer's Disease
Sukanya, BG Prajapati, VM Patil… - Deciphering Drug Targets …, 2023 - Springer
Alzheimer's disease (AD) is a multifactor disease that is a most familiar form of dementia.
Neurofibrillary tangles (NFTs) and amyloid-β (Aβ) are the neuropathological indicators of …
Neurofibrillary tangles (NFTs) and amyloid-β (Aβ) are the neuropathological indicators of …