Human Hazard Assessment Using Drosophila Wing Spot Test as an Alternative In Vivo Model for Genotoxicity Testing—A Review

P Pitchakarn, W Inthachat, J Karinchai… - International Journal of …, 2021 - mdpi.com
Genomic instability, one of cancer's hallmarks, is induced by genotoxins from endogenous
and exogenous sources, including reactive oxygen species (ROS), diet, and environmental …

Genotoxicity of copper oxide nanoparticles in Drosophila melanogaster

ER Carmona, C Inostroza-Blancheteau… - … /Genetic Toxicology and …, 2015 - Elsevier
Copper oxide nanoparticles (CuONPs) are used as semiconductors, catalysts, gas sensors,
and antimicrobial agents. We have used the comet and wing-spot assays in Drosophila …

Genotoxic and oxidative stress potential of nanosized and bulk zinc oxide particles in Drosophila melanogaster

ER Carmona… - Toxicology and …, 2016 - journals.sagepub.com
Zinc oxide nanoparticles (ZnONP) are manufactured on a large scale and can be found in a
variety of consumer products, such as sunscreens, lotions, paints and food additives. Few …

Changes in the wing shape and size in fruit flies exposed to micro and nanoplastics

RM Sorensen, D Savić-Zdravković, B Jovanović - Chemosphere, 2024 - Elsevier
Geometric morphometrics analysis (GMA) is a well-known technique to identify minute
changes in Drosophila wings. This study aimed to determine potential changes in …

Genotoxicity evaluation of metformin and glimepiride by micronucleus assay in exfoliated urothelial cells of type 2 diabetes mellitus patients

MK Harishankar, S Logeshwaran, S Sujeevan… - Food and Chemical …, 2015 - Elsevier
Micronucleus (MN) assay was performed on the exfoliated urothelial cells to detect the
genotoxic effects of the anti-hyperglycemic drugs, metformin and glimepiride in T2DM …

[HTML][HTML] High-throughput prescreening of pharmaceuticals using a genome-wide bacterial bioreporter array

T Elad, HB Seo, S Belkin, MB Gu - Biosensors and Bioelectronics, 2015 - Elsevier
We assessed the applicability of multi-strain bacterial bioreporter bioassays to drug
screening. To this end, we investigated the reactions of a panel of 15 luminescent …

Analysis of genotoxic activity of ketamine and rocuronium bromide using the somatic mutation and recombination test in Drosophila melanogaster

PM Koksal, M Gürbüzel - Environmental Toxicology and Pharmacology, 2015 - Elsevier
The present study evaluated the mutagenic and recombinogenic effects of two commonly
used anesthetic agents, ketamine and rocuronium bromide, in medicine using the wing …

Sensitivity and specificity prediction of the buccal micronucleus cytome assay in end-stage renal disease patients on dialysis: A case-control study

G Gandhi, G Tung - Mutation Research/Genetic Toxicology and …, 2017 - Elsevier
Patients with end-stage renal disease (ESRD) require hemodialysis. However, dialysis
therapy may cause genomic damage due to increased oxidative stress. Non-invasive …

Genotoxic damage in end-stage renal disease

G Gandhi, T Mehta, P Contractor, G Tung - Mutation Research/Genetic …, 2018 - Elsevier
End-stage renal disease (ESRD) patients are at increased risk for cardiovascular events and
cancer, possibly due to genomic instability associated with renal disease and/or its therapy …

Genotoxic evaluation of bupivacaine and levobupivacaine in the Drosophila wing spot test

M Gürbüzel, U Karaca, N Karayilan - Cytotechnology, 2016 - Springer
Bupivacaine and levobupivacaine are amino amide local anesthetics commonly used in
medical practice. Although bupivacaine consists of a racemic mixture of S (–)-bupivacaine …